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Elacridar hydrochloride is an inhibitor of P-glycoprotein (P-GP /ABCG1). Blocking p-GP mediated multidrug resistance (MDR) of the cytotoxic compounds doxorubicin and vincristine in CHRC5 cells. It also inhibits breast cancer drug resistance protein (BCRP/ABCG2). Be verbally active.
| Molecular Weight | 600.1 |
| Formula | C34H33N3O5.HCl |
| CAS Number | 143851-98-3 |
| Solubility (25°C) | DMSO 6 mg/mL (May need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related P-glycoprotein Products |
|---|
| LY335979 trihydrochloride
LY335979 (Zosuquidar trihydrochloride) is a selective Pgp (P-glycoprotein) inhibitor with a Ki of 59 nM. *The compound is unstable in solutions, freshly prepared is recommended |
| Biricodar
The pipecolinate derivative Biricodar (VX-710, Incel) is a clinically applicable modulator of P-glycoprotein (Pgp) with potential chemosensitizing activity. |
| Tariquidar
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| (20S)-Protopanaxadiol
(20S)-Protopanaxadiol (aPPD) is one of the aglycones of the ginsenosides and has a wide range of pharmacological activities. |
| Tenacissoside-G
Tenacissoside G is a C21 steroid from the stem of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in multidrug resistant cancer cells that overexpress p-glycoprotein (Pgp). |
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