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Molnupiravir (EIDD-2801) is an orally bioavailable form of a highly potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. EIDD-2801 (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever. Molnupiravir (EIDD-2801) is efficiently hydrolyzed in vivo after absorption, resulting in detection of only free NHC in plasma. EIDD-2801 robustly reduces MERS-CoV infectious titers, viral RNA, and pathogenesis under both prophylactic and early therapeutic conditions.
| Cell Experiment | |
|---|---|
| Cell lines | HepG2 cells |
| Preparation method | HepG2 cells were exposed in culture to increasing concentrations of Molnupiravir or NHC for 48 hours. RNA was extracted and RT-qPCR performed to quantify gene transcripts. |
| Concentrations | 0-20 μM |
| Incubation time | 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | Male and female 8- to 10-week-old Syrian Golden hamsters |
| Formulation | MK-4482 was dissolved in DMSO and then resuspended in sterile saline for delivery at 250 mg/kg |
| Dosages | 250 mg/kg |
| Administration | Oral administration |
| Molecular Weight | 329.31 |
| Formula | C13H19N3O7 |
| CAS Number | 2349386-89-4 |
| Solubility (25°C) | DMSO 50 mg/mL Water 9 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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