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EG-011 is a first-in-class, potent Wiskott-Aldrich Syndrome Protein (WASP) activator that activates the self-inhibited form of WASP via strong actin polymerization.In addition, EG-011 has selective anti-lymphoma activity.
| Molecular Weight | 482.53 |
| Formula | C28H26N4O4 |
| CAS Number | 2377113-41-0 |
| Solubility (25°C) | DMSO >100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Actin-Related Protein Products |
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| CK-636
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. |
| CK 666
Ck-666 is a cell-permeable inhibitor (IC50=12 μM) of the Arp2/3 complex, which binds to the Arp2/3 complex and stabilizes the inactive state of the complex, preventing the movement of Arp2 and Arp3 subunits into the active filamentous conformation. |
| CK 869
Ck-869 is an inhibitor of the actin associated protein 2/3 complex (ARP2/3) with an IC50 value of 7 μM. |
| Latrunculin A
Latrunculin A (Latrunculia magnifica) is A toxin obtained from the Red Sea sponge Latrunculia magnifica that binds to actin monocytes and inhibits actin aggregation, inhibiting atP-actin, ADP-pi-actin, Kd values of ADP-actin and G-actin were 0.1, 0.4, 4.7 μM and 0.19 μM, respectively. |
| SMIFH2
SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation. |
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