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Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Eeyarestatin I specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Eeyarestatin I also inhibits Sec61-mediated protein translocation at the ER. Eeyarestatin I displays cytotoxic activity preferentially against cancer cells; Eeyarestatin I induces cell death via the proapoptotic protein NOXA.
| Molecular Weight | 630.44 |
| Formula | C27H25Cl2N7O7 |
| CAS Number | 412960-54-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | -20°C, dry, sealed |
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