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E1210

Cat. No. M9503

All AbMole products are for research use only, cannot be used for human consumption.

E1210 Structure
Synonym:

APX001A; Manogepix

Size Price Availability Quantity
10mM*1mL in DMSO USD 150 In stock
1mg USD 55 In stock
5mg USD 135 In stock
10mg USD 215 In stock
25mg USD 450 In stock
50mg USD 760 In stock
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Quality Control & Documentation
Biological Activity

E1210 inhibits the inositol acylation activity of C. albicans Gwt1p and A. fumigatus Gwt1p with IC50s of 0.3 to 0.6 μM. E1210 inhibits germ tube formation, adherence to polystyrene surfaces, and biofilm formation of C. albicans at concentrations above its MIC. In vivo, E1210 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; oral administration; twice daily; for 3 days; specific-pathogen-free female ICR mice) treatment reduces the number of viable C. albicans cells in the oral cavity in a dose-dependent manner.

Chemical Information
Molecular Weight 358.39
Formula C21H18N4O2
CAS Number 936339-60-5
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Watanabe NA, et al. Antimicrob Agents Chemother. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis.

[2] Hata K, et al. Antimicrob Agents Chemother. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis.

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Keywords: E1210, APX001A; Manogepix supplier, Anti-infection, inhibitors, activators

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