Free shipping on all orders over $ 500

(E/Z)-BCI

Cat. No. M20734

All AbMole products are for research use only, cannot be used for human consumption.

(E/Z)-BCI Structure
Synonym:

BCI, NSC 150117

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

Chemical Information
Molecular Weight 317.42
Formula C22H23NO
CAS Number 15982-84-0
Solubility (25°C) DMSO 63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hasan Onur Caglar, et al. Gene. Identification of upregulated genes in glioblastoma and glioblastoma cancer stem cells using bioinformatics analysis

[2] Boya Zhang, et al. Cell Death Dis. DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling

[3] Nicole E James, et al. Oncotarget. Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes

[4] Fan Zhang, et al. Inflammation. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway

[5] Qi-Nian Wu, et al. Cancer Lett. Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance

Related Phosphatase Products
CCT007093

CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.
Microcystin-LR

Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.
Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
Razuprotafib

Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM).
β-Glycerophosphate disodium salt hydrate

β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers.
  Catalog
Abmole Inhibitor Catalog




Keywords: (E/Z)-BCI, BCI, NSC 150117 supplier, Phosphatase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.