All AbMole products are for research use only, cannot be used for human consumption.
Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore inhibits HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes. Dynasore reduces the number of viral capsids reaching the nuclear pore if added at the time of viral entry and that, when added as late as 8 h postentry, dynasore blocks the transport of newly synthesized viral proteins from the nucleus to the cytosol.
Nat Cell Biol. 2026 Feb 12; .
THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria
Dynasore purchased from AbMole
Med Microbiol Immunol. 2024 Oct 23;213(1):23.
The pathogenic responses elicited during exposure of human intestinal cell line with Giardia duodenalis excretory-secretory products and the potential attributed endocytosis mechanism
Dynasore purchased from AbMole
J Med Virol. 2023 Jan;95(1).
Enterovirus-71 utilizes small extracellular vesicles to cross the blood-brain barrier for infecting the central nervous system via transcytosis
Dynasore purchased from AbMole
Adv Sci (Weinh). 2022 Jul;9(21):e2201414.
Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport
Dynasore purchased from AbMole
Int J Pharm. 2022 Feb 14;617:121589.
Lipid raft-mediated and upregulated coordination pathways assist transport of glycocholic acid-modified nanoparticle in a human breast cancer cell line of SK-BR-3
Dynasore purchased from AbMole
Patent. CN109939269B 2021 Nov 30.
Patent. CN109939269B
Dynasore purchased from AbMole
Patent. CN109939269A 2021-11-30.
Patent. CN109939269A
Dynasore purchased from AbMole
Patent. CN109939269A 2021 Nov 30; .
Patent. CN109939269A
Dynasore purchased from AbMole
FEBS Lett. 2019 Mar;593(5):504-517.
Endocytosis-dependent lysosomal degradation of Src induced by protease-activated receptor 1.
Dynasore purchased from AbMole
| Molecular Weight | 322.31 |
| Formula | C18H14N2O4 |
| CAS Number | 304448-55-3 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Giulio Preta, et al. Dynasore - not just a dynamin inhibitor
[5] Eric Macia, et al. Dynasore, a cell-permeable inhibitor of dynamin
| Related Dynamin Products |
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| Mdivi-1
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. |
| Hydroxy-Dynasore
Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin a heavy chain binding domain (BoNT/A-Hc). |
| TAT-P110
TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1. |
| Anti-inflammatory agent 49
Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. Anti-inflammatory agent 49 inhibits GTPase with IC50 of 270 nM in vitro. Anti-inflammatory agent 49 can be used in the study of diseases caused by mitochondrial dysfunction. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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