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Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 431.5 |
| CAS Number | 2222768-84-3 |
| Solubility (25°C) | DMSO 83.33 mg/mL |
| Storage | 2-8°C, protect from light |
[3] Susanne Hing, et al. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein
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