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Duocarmycin A 

Cat. No. M27896

All AbMole products are for research use only, cannot be used for human consumption.

Duocarmycin A  Structure

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Quality Control & Documentation
Biological Activity

Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels.

Chemical Information
Molecular Weight 507.49
Formula C26H25N3O8
CAS Number 118292-34-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] H Sugiyama, et al. Tetrahedron Lett. A novel guanine N3 alkylation by antitumor antibiotic duocarmycin A

[2] Lin Yu, et al. Oncotarget. Promiximab-duocarmycin, a new CD56 antibody-drυg conjugates, is highly efficacious in small cell lung cancer xenograft models

[3] Amanda L Wolfe, et al. J Med Chem. A novel, unusually efficacious duocarmycin carbamate prodrυg that releases no residual byproduct

[4] C H Lin, et al. J Mol Biol. Solution structure of the covalent duocarmycin A-DNA duplex complex

[5] I Takahashi, et al. J Antibiot (Tokyo). Duocarmycin A, a new antitumor antibiotic from Streptomyces

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