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DSM265 is a long-acting inhibitor of Plasmodium falciparum dihydroorotic acid dehydrogenase (PfDHODH) with an IC50 value of 8.9 nM. In addition, DSM265 inhibits the growth of Pf3D7 with an EC50 value of 4.3 nM.
| Molecular Weight | 415.33 |
| Formula | C14H12F7N5S |
| CAS Number | 1282041-94-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL Ethanol 11.11 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DHODH Products |
|---|
| Leflunomide
Leflunomide (HWA486) is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM. |
| Teriflunomide
Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent. |
| Vidofludimus
Vidofludimus (4SC-101; SC12267) is an immunosuppressant that inhibits DHODH and inhibits il-17 secretion without affecting lymphocyte proliferation. |
| Brequinar
Brequinar is an effective Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 5.2 nM for human DHODH, and a broad-spectrum antiviral agent. |
| Orludodstat (BAY-2402234)
BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM. |
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