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DS1

Cat. No. M7740

All AbMole products are for research use only, cannot be used for human consumption.

DS1 Structure

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Biological Activity

δ-GABAA receptors are emerging as an important pharmacological target. DS1 potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors. It had little effect on GABA responses mediated by α4β3γ2 receptors. At similar concentrations DS1 directly activates this receptor and is the most potent known agonist of α4β3δ receptors. This compound has an opportunity to be become an agonist golden stardard for δ-GABAA receptors.

Chemical Information
Molecular Weight 511.62
Formula C18H10Br2ClN3OS
CAS Number 372497-52-4
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] X Liu, et al. DS1/OsEMF1 interacts with OsARF11 to control rice architecture by regulation of brassinosteroid signaling

[2] Yuh-Chyang Charng, et al. The Ds1 Transposon Provides Messages That Yield Unique Profiles of Protein Isoforms and Acts Synergistically With Ds to Enrich Proteome Complexity via Exonization

[3] Tselmeg Mijiddorj, et al. DS1, a delta subunit-containing GABA(A) receptor agonist, increases gonadotropin subunit gene expression in mouse pituitary gonadotrophs

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Keywords: DS1 supplier, inhibitors, activators

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