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DPN

Cat. No. M4835

All AbMole products are for research use only, cannot be used for human consumption.

DPN Structure
Synonym:

Diarylpropionitrile

Size Price Availability Quantity
5mg USD 40 In stock
10mg USD 65 In stock
50mg USD 250 In stock
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Quality Control & Documentation
Biological Activity

DPN increased GluR2 expression in the other lamina of the CA1.DPN acts as an agonist on both ER subtypes, but has a 70-fold higher relative binding affinity and 170-fold higher relative potency in transcription assays with ERbeta than with ERalpha. DPN displayed subtype-selective agonism, being ca. 30-fold more potent through ERbeta.Both PPT and DPN can acutely relax isolated mesenteric arteries with the relative potency of PPT>17beta-oestrogen>DPN.

Chemical Information
Molecular Weight 239.27
Formula C15H13NO2
CAS Number 1428-67-7
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Waters EM, et al. Brain Res. Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus.

[2] Harrington WR, et al. Mol Cell Endocrinol. Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression.

[3] Montgomery S, et al. Br J Pharmacol. Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility.

[4] Meyers MJ, et al. J Med Chem. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.

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Keywords: DPN, Diarylpropionitrile supplier, Estrogen Receptor, inhibitors, activators

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