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DPM-1001 

Cat. No. M28513

All AbMole products are for research use only, cannot be used for human consumption.

DPM-1001  Structure

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Quality Control & Documentation
Biological Activity

DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property.

Chemical Information
Molecular Weight 567.85
Formula C35H57N3O3
CAS Number 1471172-27-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder -20°C
References

[1] Navasona Krishnan, et al. Genes Dev. DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease

[2] Navasona Krishnan, et al. J Biol Chem. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models

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  Catalog
Abmole Inhibitor Catalog




Keywords: DPM-1001  supplier, Phosphatase, inhibitors, activators

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