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Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant.
| Molecular Weight | 315.84 |
| Formula | C19H21NO.HCl |
| CAS Number | 1229-29-4 |
| Solubility (25°C) | DMSO 80 mg/mL Water 40 mg/mL |
| Storage | 4°C, dry, sealed |
[1] Eric Matheson, et al. Insomnia: Pharmacologic Therapy
[2] Haramandeep Singh, et al. Novel therapeutic usage of low-dose doxepin hydrochloride
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