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Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
| Molecular Weight | 432.98 |
| Formula | C24H30N2O2.HCl.H2O |
| CAS Number | 7081-53-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 70 mg/mL Water 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Robert B Flint, et al. The bioavailability and maturing clearance of doxapram in preterm infants
[2] Cornelia G de Waal, et al. Doxapram Treatment and Diaphragmatic Activity in Preterm Infants
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TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM. |
| ML133 hydrochloride
ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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