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DOV 216,303

Cat. No. M7767

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DOV 216,303 Structure

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Quality Control & Documentation
Biological Activity

DOV 216,303 is a potent triple inhibitor of 5-hydroxytryptamine (5-HT), norepinephrine, and dopamine reuptake with IC50 values of 20, 14, and 78 nM, respectively.

Chemical Information
Molecular Weight 264.58
Formula C11H11Cl2N · HCl
CAS Number 86215-36-3
Solubility (25°C) DMSO ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tak-Ho Chu, et al. The triple monoamine re-uptake inhibitor DOV 216,303 promotes functional recovery after spinal cord contusion injury in mice

[2] Gunnar Srensen, et al. Addiction-related effects of DOV 216,303 and cocaine: A comparative study in the mouse

[3] J Prins, et al. The potential and limitations of DOV 216,303 as a triple reuptake inhibitor for the treatment of major depression: a microdialysis study in olfactory bulbectomized rats

[4] Bernard Beer, et al. DOV 216,303, a "triple" reuptake inhibitor: safety, tolerability, and pharmacokinetic profile

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  Catalog
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Keywords: DOV 216,303 supplier, 5-HT Receptor, inhibitors, activators

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