All AbMole products are for research use only, cannot be used for human consumption.
DOTMA, as a tetra-methylated DOTA analogue, is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA is applied to DNA delivery. Studies have found that single-compartment liposomes prepared by DOTMA can encapsulate DNA and RNA fragments at a high level, with an encapsulation rate of 100%, and can be well taken up by cells to express target genes. The transfection efficiency at the cellular level is 10 times higher than that of DOTAP. The prescription is also simpler, and there is no need to add helper lipids such as DOPE.
Patent. CN120966886A 2025 Nov 18; .
Patent. CN120966886A
DOTMA purchased from AbMole
| Molecular Weight | 670.57 |
| Formula | C42H84ClNO2 |
| CAS Number | 104872-42-6 |
| Solubility (25°C) | DMSO 10 mg/mL (ultrasonic and warming and heat to 50°C) |
| Storage | -20°C, protect from light, dry, sealed |
[3] Yu Zhang, et al. J Control Release. Progress in microRNA delivery
[5] R W Malone, et al. Proc Natl Acad Sci U S A. Cationic liposome-mediated RNA transfection
| Related Cell Transfection Products |
|---|
| Chitosan (MW 100000)
Chitosan is a natural polycationic linear polysaccharide derived from chitin. |
| Hexadimethrine bromide
Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections.In addition, Polybrene can be used as a promoter in virus-mediated gene therapy assays and in studies of gene transfer. |
| DOTAP chloride
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids. |
| DSPE-PEG-2K-Amine
DSPE-PEG-2K-Amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE, used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents. |
| DOPE
DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
