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Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
| Molecular Weight | 324.44 |
| Formula | C10H16N2O4S3 |
| CAS Number | 120279-96-1 |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Thorsteinn Loftsson, et al. Topical drug delivery to the eye: dorzolamide
[3] Jens Martens-Lobenhoffer, et al. Clinical pharmacokinetics of dorzolamide
| Related Carbonic Anhydrase Products |
|---|
| Benzthiazide
Benzthiazide is a thiazide diuretic, promoting water loss from the body. |
| Brinzolamide
Brinzolamide (Brinzolamide) is a potent and effective carbonic anhydrase-II inhibitor with an IC50 of 3.19 nM.In addition, Brinzolamide reduces intraocular aqueous humor production in the eye and may be used in studies related to glaucoma. |
| Ethoxzolamide
Ethoxzolamide is an inhibitor of the metalloenzyme carbonic anhydrase, which inhibits hCA I, hCA II, hCA IV, hCA VI and hCA VII with Ki of 25 nM, 8 nM, 93 nM, 43 nM and 0.8 nM, respectively. |
| Fluorometholone Acetate
Fluorometholone Acetate is a synthetic corticosteroid and a potent carbonic anhydrase (CA) inhibitor with IC50s of 2.18 μM for hCA-I and 17.5 μM for hCA-II. It has anti-inflammatory activity and may be used in studies related to steroid-responsive ocular inflammation. |
| Methazolamide
Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. |
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