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Dorzolamide HCl

Cat. No. M5591

All AbMole products are for research use only, cannot be used for human consumption.

Dorzolamide HCl Structure
Synonym:

MK-507 (L-671152) HCl

Size Price Availability Quantity
5mg USD 45 In stock
10mg USD 65 In stock
50mg USD 120 In stock
100mg USD 170 In stock
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Quality Control & Documentation
Biological Activity

Dorzolamide HCl is a water-soluble inhibitor of human carbonic anhydrase carbonic anhydrase II and IV with a Ki of 1.9 nM and 31 nM, respectively, and can be used in glaucoma-related studies.

Chemical Information
Molecular Weight 360.9
Formula C10H16N2O4S3.HCl
CAS Number 130693-82-2
Form Solid
Solubility (25°C) 14 mg/mL in water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jóhannesson G, et al. J Ocul Pharmacol Ther. Dorzolamide cyclodextrin nanoparticle suspension eye drops and Trusopt in rabbit.

Related Carbonic Anhydrase Products
Benzthiazide

Benzthiazide is a thiazide diuretic, promoting water loss from the body.

Brinzolamide

Brinzolamide (Brinzolamide) is a potent and effective carbonic anhydrase-II inhibitor with an IC50 of 3.19 nM.In addition, Brinzolamide reduces intraocular aqueous humor production in the eye and may be used in studies related to glaucoma.

Ethoxzolamide

Ethoxzolamide is an inhibitor of the metalloenzyme carbonic anhydrase, which inhibits hCA I, hCA II, hCA IV, hCA VI and hCA VII with Ki of 25 nM, 8 nM, 93 nM, 43 nM and 0.8 nM, respectively.

Fluorometholone Acetate

Fluorometholone Acetate is a synthetic corticosteroid and a potent carbonic anhydrase (CA) inhibitor with IC50s of 2.18 μM for hCA-I and 17.5 μM for hCA-II. It has anti-inflammatory activity and may be used in studies related to steroid-responsive ocular inflammation.

Methazolamide

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

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Keywords: Dorzolamide HCl, MK-507 (L-671152) HCl supplier, Carbonic Anhydrase, inhibitors, activators

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