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Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a glucokinase (GK) activator, which improves glycaemic control and pancreatic β-cell function for type 2 diabetes.
BioRxiv. 2024 Nov 09;622781.
Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of GCK-MODY
Dorzagliatin purchased from AbMole
| Molecular Weight | 462.93 |
| Formula | C22H27ClN4O5 |
| CAS Number | 1191995-00-2 |
| Solubility (25°C) | DMSO 93 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Glucokinase (GK) Products |
|---|
| LY2608204
LY2608204 activates glucokinase (GK) with EC50 of 42 nM. |
| AM2394
AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM. |
| AZD1656
AZD1656 is a potent, selective and orally active glucokinase (GK) activator, with an EC50 of 60 nM. |
| Cadisegliatin (TTP-399)
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes. |
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