All AbMole products are for research use only, cannot be used for human consumption.
Donepezil hydrochloride is a centrally acting reversible acetylcholinesterase inhibitor (AChEI) with an IC50 of 12.3 nM. Its main therapeutic use is in the treatment of Alzheimer’s disease where it is used to increase levels of cortical acetylcholine. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier.
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| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Male Lister Hooded rats |
| Formulation | 0.9% w:v NaCl (saline) |
| Dosages | 18 μM/kg |
| Administration | Administered via i.p. or p.o. |
| Molecular Weight | 416 |
| Formula | C24H29NO3.HCl |
| CAS Number | 120011-70-3 |
| Solubility (25°C) | Water 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related AChR/AChE Products |
|---|
| VU 0255035
VU 0255035 is a highly selective M1 muscarinic acetylcholine receptor (mAChR) antagonist (Ki = 14.87 nM). |
| Fesoterodine fumarate
Fesoterodine fumarate (Toviaz) is a novel muscarinic receptor antagonist. |
| SVT-40776
SVT-40776 is a novel M3 muscarinic receptor antagonist. |
| Aniracetam
Aniracetam is a compound that promotes intellectual development and neuroprotection. |
| Biperiden hydrochloride
Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. |
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