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DNMDP 

Cat. No. M29915

All AbMole products are for research use only, cannot be used for human consumption.

DNMDP  Structure
Size Price Availability Quantity
1mg USD 70 In stock
5mg USD 150 In stock
10mg USD 220 In stock
25mg USD 440 In stock
50mg USD 720 In stock
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Quality Control & Documentation
Biological Activity

DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity.

Chemical Information
Molecular Weight 304.34
Formula C15H20N4O3
CAS Number 328104-79-6
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jie Chen, et al. Nat Commun. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells

[2] Colin W Garvie, et al. Nat Commun. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

[3] Xiaoyun Wu, et al. J Biol Chem. Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

[4] Timothy A Lewis, et al. ACS Med Chem Lett. Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing

[5] Luc de Waal, et al. Nat Chem Biol. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

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  Catalog
Abmole Inhibitor Catalog




Keywords: DNMDP  supplier, PDE, inhibitors, activators

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