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DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6), produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies. DLin-KC2-DMA (24 h) exhibits high uptake into macrophages and dendritic cells. DLin-KC2-DMA efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway. DLin-KC2-DMA displays almost no toxicity in primary APCs.
| Molecular Weight | 642.09 |
| Formula | C43H79NO2 |
| CAS Number | 1190197-97-7 |
| Form | Liquid |
| Solubility (25°C) | DMSO 100 mg/mL Ethanol 100 mg/mL |
| Storage | -20°C, sealed |
[5] Sean C Semple, et al. Nat Biotechnol. Rational design of cationic lipids for siRNA delivery
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