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Dizocilpine (MK-801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
Brain Res. 2025 Mar 14; .
Modulating excitation of the mediodorsal thalamus rescues dysfunction after administration of MK-801 in rats
Dizocilpine purchased from AbMole
Patent. CN112137996B 2023 Aug 25.
Patent. CN112137996B
Dizocilpine purchased from AbMole
| Molecular Weight | 221.3 |
| Formula | C16H15N |
| CAS Number | 77086-21-6 |
| Solubility (25°C) | DMSO 23 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] K Harsha Vardhan Reddy, et al. Convergent Strategy to Dizocilpine MK-801 and Derivatives
[4] L J Vanderschuren, et al. Dizocilpine (MK801): use or abuse?
| Related NMDA Products |
|---|
| D-Cycloserine
D-Cycloserine is an analog of the amino acid D-alanine. |
| D-AP5
D-AP5 is a potent, selective NMDA antagonist. |
| Homoquinolinic acid
Homoquinolinic acid is a selective, potent NMDA agonist. |
| Ibotenic acid
Ibotenic acid is a non-selective NMDA agonist. Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. |
| Quinolinic acid
Quinolinic acid is a endogenous NMDA agonist and transmitter candidate. |
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