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Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevention of both manic and depressive phases of bipolar disorder, especially the rapid-cycling variant. It is also used in the US for the treatment of epilepsy, chronic pain associated with neuropathy, and migraine headaches. Its chemical name is sodium hydrogen bis (2-propylpentanoate). The extended release formulation allows for a single daily dose.
| Molecular Weight | 310.41 |
| Formula | C8H16O2.C8H15O2.Na |
| CAS Number | 76584-70-8 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Lori L Davis, et al. Divalproex sodium in the treatment of adults with bipolar disorder
[3] Manasi Rana, et al. Divalproex sodium in the treatment of pediatric psychiatric disorders
[4] Crystal E Pratt, et al. Divalproex sodium therapy in elderly with dementia-related agitation
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