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Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity.
| CAS Number | 2136633-23-1 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[3] Hélène Kaplon, et al. MAbs. Antibodies to watch in 2022
| Related Drug-Linker Conjugates for ADC Products |
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| Mc-Val-Cit-PABC-PNP
Mc-Val-Cit-PABC-PNP is a histone-cleavable peptide linker for antibody-drug couplings (ADCs) that can be used for the synthesis of ADCs such as Brentuximab vedotin. |
| DM1-SMCC
DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC. |
| CL2A-SN-38
CL2A-SN-38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an ADC. |
| BS3 (bis(sulfosuccinimidyl)suberate)
BS3 (bis(sulfosuccinimidyl)suberate) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| Sulfo-SMCC sodium
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively. |
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