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Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively. DPI chloride has been used to inhibit other flavoenzymes such as neutrophil NADPH oxidase and to bind strongly to flavoproteins. DPI chloride is thus a powerful and specific inhibitor of several important enzymes, including NADPH cytochrome P450 oxidoreductase, NADPH oxidases and NADPH-ubiquinone oxidoreductase.
| Molecular Weight | 314.55 |
| Formula | C12H8I.Cl |
| CAS Number | 4673-26-1 |
| Solubility (25°C) | DMSO 6 mg/mL (with warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NO Synthase Products |
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| 2-Thiouracil
2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent. |
| Imperatorin
Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM. |
| Crocin-II
Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA. |
| Madecassic-acid
Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages. |
| Irisflorentin
Irisflorentin, a naturally occurring isoflavone, is an abundant active ingredient in Rhizoma Belamcandae. Irisflorentin significantly reduced the transcription and translation levels of iNOS and NO production. |
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