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Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB).
| Molecular Weight | 255.35 |
| Formula | C17H21NO |
| CAS Number | 58-73-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ruby Hoang et al. Clin Toxicol (Phila). Diphenhydramine overdose with neuromuscular excitation
[2] Anna R Wolfson et al. J Allergy Clin Immunol Pract. Diphenhydramine: Time to Move on?
[4] Timothy Nguyen et al. Am J Ther. Diphenhydramine Use in End-Stage Kidney Disease
| Related Histamine Receptor Products |
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Ciproxifan is an orally bioavailable, extremely potent histamine H3 inverse agonist/antagonist. |
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| Azacyclonol
Azacyclonol, also known as γ-pipradol, which diminishes hallucinations in psychotic individuals. |
| Azatadine dimaleate
Azatadine dimaleate is an antihistamine and anticholinergic compound with IC50 of 6.5nM and 10nM, respectively. |
| Bepotastine Besilate
Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7. |
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