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Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB). Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
| Molecular Weight | 291.82 |
| Formula | C17H21NO.HCl |
| CAS Number | 147-24-0 |
| Solubility (25°C) | DMSO 90 mg/mL Water 90 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Related Histamine Receptor Products |
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