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Diosimin is a flavonoid glycoside found in citrus fruits, hyssop, and rosemary. Diosimin is also an agonist of the aryl hydrocarbon receptor (AhR), capable of upregulating the expression of p53, caspase 3, and caspase 9 in A431 cells, while downregulating the levels of Bcl-2 and matrix metalloproteinases (MMP-2 and MMP-9). Its metabolite, diosmetin, inhibits 3H-dopamine uptake in a dose-dependent manner with an IC50 value of 4 μM.
| Molecular Weight | 608.54 |
| Formula | C28H32O15 |
| CAS Number | 520-27-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Samar H Gerges, et al. Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review
[2] Nemat Ali, et al. Protective effect of diosmin against doxorubicin-induced nephrotoxicity
[4] Tingting Li, et al. Diosmin for the prevention of ovarian hyperstimulation syndrome
| Related Aryl hydrocarbon Receptor Products |
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| StemRegenin 1
StemRegenin 1 is an AhR inhibitor with IC50 of 127 nM. |
| Carbidopa
Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. |
| CH-223191
CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| Perillaldehyde
Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. |
| YH439
Mivotilate (YH439) is a potent activator of the aryl hydrocarbon receptor (AhR). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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