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Diosgenin is a plant steroid which induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. Diosgenin can inhibit STAT3 signaling pathway.
International Journal of Pharmacology. 2025 Jun 12;811-7775.
Research Article Inhibition of Microglia Synaptic Pruning Mediates the Anti-Neuroinflammatory Activity of Diosgenin
Diosgenin purchased from AbMole
J Affect Disord. 2023 Jan 15;321:242-252.
Gut microbiota mediated inflammation, neuroendocrine and neurotrophic functions involved in the antidepressant-like effects of diosgenin in chronic restraint stress
Diosgenin purchased from AbMole
| Molecular Weight | 414.62 |
| Formula | C27H42O3 |
| CAS Number | 512-04-9 |
| Solubility (25°C) | chloroform 5 mg/mL ethanol 8 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Prajya Arya, et al. Diosgenin a steroidal compound: An emerging way to cancer management
[2] Shi-Qing Zhang, et al. Research on anti-tumor natural product diosgenin
[3] Zhongyi Sun, et al. Pathway design and key enzyme analysis of diosgenin biosynthesis
[5] Fang-Chun Wu, et al. Effects of diosgenin and its derivatives on atherosclerosis
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| Fludarabine
Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. |
| Niclosamide
Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM. |
| Nifuroxazide
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Products are for research use only. Not for human use. We do not sell to patients.
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