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Dimethyl-lithospermate-B

Cat. No. M4148

All AbMole products are for research use only, cannot be used for human consumption.

Dimethyl-lithospermate-B Structure
Synonym:

dmLSB

Size Price Availability Quantity
1mg USD 220 In stock
5mg USD 600 In stock
10mg USD 900 In stock
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Quality Control & Documentation
Biological Activity

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows sodium current (INa) inactivation, resulting in an early increase in inward current of the action potential (AP).

Chemical Information
Molecular Weight 746.67
Formula C38H34O16
CAS Number 875313-64-7
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jun-Feng Gao, et al. Chemical constituents of Salvia chinensis

[2] Eunyoung Lim, et al. Synthesis of a dual-labeled probe of dimethyl lithospermate B with photochemical and fluorescent properties

[3] Zheng-Fu Zhang, et al. Studies on polyphenolic chemical constitutents from root of Salvia yunnansis

[4] Jeffrey M Fish, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome

[5] Jin-Young Yoon, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes

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Keywords: Dimethyl-lithospermate-B, dmLSB supplier, Sodium Channel, inhibitors, activators

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