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DIM-C-pPhtBu

Cat. No. M8307

All AbMole products are for research use only, cannot be used for human consumption.

DIM-C-pPhtBu Structure

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Biological Activity

DIM-C-pPhtBu, similar to other C-DIMs, exhibits a broad range of anticancer and antitumorigenic activities against multiple tumor types. DIM-C-pPhtBu causes apoptotic cell death of KB cells by activation of endoplasmic reticulum stress through induction of CHOP protein that is associated with the apoptosis in human oral cancer cells. Also it appears to induce an autophagic cell death in drug-resistant ER-negative breast tumors.

Chemical Information
Molecular Weight 378.51
Formula C27H26N2
CAS Number 94944-80-6
Solubility (25°C) DMSO: ≥15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sung Un Kang, et al. DIM-C-pPhtBu induces lysosomal dysfunction and unfolded protein response - mediated cell death via excessive mitophagy

[2] Ji-Ae Shin, et al. Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells

[3] Kathy Vanderlaag, et al. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

[4] Jun Hong, et al. 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines

[5] Maen Abdelrahim, et al. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5

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Keywords: DIM-C-pPhtBu supplier, inhibitors, activators

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