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Dihydromyricetin (DHM), a natural flavonoid, exerts various bioactivities including anti-oxidative and hepatoprotective effects.Dihydromyricetin can protect HUVECs from oxidative stress damage, an effect that is mediated by the mitochondrial apoptotic pathways.Dihydromyricetin showed great antioxidative effect and would be a good natural antioxidant.Dihydromyricetin anti-alcohol effects on both behavior and CNS neurons were antagonized by flumazenil (10 mg/kg in vivo, 10 μM in vitro), the benzodiazepine (BZ) antagonist. Dihydromyricetin competitively inhibited BZ-site [3H]flunitrazepam binding (IC50, 4.36 μM), suggesting DHM interaction with EtOH involves the BZ-sites on GABAARs.
| Molecular Weight | 320.25 |
| Formula | C15H12O8 |
| CAS Number | 27200-12-0 |
| Solubility (25°C) | DMSO 64mg/ml Ethanol 64mg/ml |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Yi Shen, et al. J Neurosci. Dihydromyricetin As A Novel Anti-Alcohol Intoxication Medication.
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