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Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.
| Molecular Weight | 400.51 |
| Formula | C20H36N2O6 |
| CAS Number | 126463-64-7 |
| Solubility (25°C) | DMSO: ≥1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] J D Gough, et al. Probing protein function with small molecules
[5] N Sin, et al. Eponemycin analogues: syntheses and use as probes of angiogenesis
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