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Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism.
| Cell Experiment | |
|---|---|
| Cell lines | C6 glioma cell |
| Preparation method | The BrdU-LI positive C6 glioma cell population was reduced to 37% in the cultures treated with 20 µM dihydroartemisinin for 48 h compared with the control cultures. Reduction in the BrdU-LI indicated a decrease in the uptake of BrdU by C6 glioma cells. |
| Concentrations | 20 µM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J male mice |
| Formulation | - |
| Dosages | 10, 25, and 50 mg/kg |
| Administration | Oral |
| Molecular Weight | 284.35 |
| Formula | C15H24O5 |
| CAS Number | 71939-50-9 |
| Solubility (25°C) | DMSO 25 mg/mL Ethanol 9 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Xiaoshuo Dai, et al. Dihydroartemisinin: A Potential Natural Anticancer Drug
[2] Zhiyong Wang, et al. Dihydroartemisinin prevents palmitate-induced β-cell apoptosis
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