Digoxin

Cat. No. M3935

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

12β-Hydroxydigitoxin

Size	Price	Availability
50mg	USD 70	Out of stock
100mg	USD 100	Out of stock

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Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure.

	Source	Nature (2011). Figure 4. Digoxin
	Method	Flow cytometry
	Cell Lines	Th17 cells
	Concentrations	10 μM
	Incubation Time	6 d
	Results	In vitro digoxin treatment of expanded mouse Th17 cells derived from immunized mice inhibited both IL-23R (Fig. 4a) and IL-17a expression without affecting IFN-γ expression (Fig. 4b).

	Source	Nature (2011). Figure 1. Digoxin
	Method	luciferase reporter
	Cell Lines	Drosophila S2 cell
	Concentrations	10 μM
	Incubation Time
	Results	Inhibition of RORγ activity by digoxin was specific, as there was no effect on the transcriptional activity of VP16 or of the related nuclear hormone receptors RORα and DHR3

Cell Experiment
Cell lines	A549 cells
Preparation method	Cells were treated with various concentrations of digoxin for 24 h and seeded in transwell chambers (8-μm pore size, 6.5-mm diameter), which were or were not coated with Matrigel. The upper wells were filled with serum-free media and A549 cells (2×104 or 1×104 cells per well). The lower wells of the transwells contained the same media with 10% FBS and digoxin at various concentrations.
Concentrations	250 nM
Incubation time	24 h

Animal Experiment
Animal models	Sprague Dawley Rats
Formulation	0.5% sodium carboxymethylcellulose
Dosages	25.6 μmol/kg
Administration	oral gavage

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