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Diflapolin

Cat. No. M14087

All AbMole products are for research use only, cannot be used for human consumption.

Diflapolin Structure

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Biological Activity

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of  30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM).

Chemical Information
Molecular Weight 458.36
CAS Number 724453-98-9
Solubility (25°C) DMSO 83.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christian Grune, et al. Encapsulation of the Anti-inflammatory Dual FLAP/sEH Inhibitor Diflapolin Improves the Efficiency in Human Whole Blood

[2] Lisa Vieider, et al. Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

[3] Ulrike Garscha, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

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Keywords: Diflapolin supplier, Epoxide Hydrolase, inhibitors, activators

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