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Didox

Cat. No. M8770

All AbMole products are for research use only, cannot be used for human consumption.

Didox Structure
Synonym:

N,3,4-Trihydroxybenzamide

Size Price Availability Quantity
5mg USD 60 In stock
10mg USD 80 In stock
25mg USD 170 In stock
50mg USD 260 In stock
100mg USD 400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Didox is a ribonucleotide reductase (RNR) inhibitor that inhibits proliferation of and decreased secretion of cytokines IL-6, IFN-g, TNF-a, IL-2, IL-13, IL-10 and IL-4. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells. Didox is an antioxidant that potentiates the cytotoxic profile of doxorubicin.

Chemical Information
Molecular Weight 169.13
Formula C7H7NO4
CAS Number 69839-83-4
Solubility (25°C) DMSO: 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Juliete A F Silva, et al. Didox (3,4-dihydroxybenzohydroxamic acid) reduces the vascular inflammation induced by acute intravascular hemolysis

[2] Michela Asperti, et al. The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells

[3] Jamie Josephine Avila McLeod, et al. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription

[4] Heather L Caslin, et al. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells

[5] Ahmed M Al-Abd, et al. Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity

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Keywords: Didox, N,3,4-Trihydroxybenzamide supplier, inhibitors, activators

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