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Dicycloamine is an anticholinergic compound, a chemical released by nerves that stimulate muscle by blocking acetylcholine receptors on smooth muscle, a type of muscle.
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Source | Neurobiol Dis (2015). Figure 6. Dicyclomine hydrochloride |
| Method | i.p. | |
| Cell Lines | C57BL/6mice | |
| Concentrations | 25 mg/kg | |
| Incubation Time | 30 min | |
| Results | Famotidine (50 mg/kg) significantly reduced three-paw dyskinesia, an effect mimicked by dicyclomine |
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Source | Neurobiol Dis (2015). Figure 5. Dicyclomine hydrochloride |
| Method | i.p. | |
| Cell Lines | C57BL/6mice | |
| Concentrations | 45 mg/kg | |
| Incubation Time | 120 min | |
| Results | Summing dyskinesia scores over the entire time frame of LID testing from 0 to 120 min revealed that the higher doses of famotidine (3 and 10 mg/kg) or dicyclomine (45 mg/kg) significantly reduced total dyskinetic behavior |
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats |
| Formulation | 0.9% saline |
| Dosages | 16, 32, or 64 mg/kg |
| Administration | i.p. |
| Molecular Weight | 345.95 |
| Formula | C19H36ClNO2 |
| CAS Number | 67-92-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Fesoterodine fumarate (Toviaz) is a novel muscarinic receptor antagonist. |
| SVT-40776
SVT-40776 is a novel M3 muscarinic receptor antagonist. |
| Aniracetam
Aniracetam is a compound that promotes intellectual development and neuroprotection. |
| Biperiden hydrochloride
Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. |
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