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Dictamine

Cat. No. M4557

All AbMole products are for research use only, cannot be used for human consumption.

Dictamine Structure
Synonym:

Dictamnine; Dectamine

Size Price Availability Quantity
20mg USD 200 In stock
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Quality Control & Documentation
Biological Activity

Dictamnine (Dictamine) is cytotoxic to human cervical and colon cancer cells, and also has antibacterial and antifungal activities.

Customer Product Validations & Biological Datas
Source Asian Pac J Cancer Prev (2013). Figure 3. Dictamine
Method Apoptosis assay
Cell Lines A549 cell line
Concentrations 300 and 500 μM
Incubation Time 24 h
Results However, after exposure to 300 and 500 μM Dic for 24 h, cells with typical morphologic changes of apoptosis that chromatin condensation and shrunken nucleus (Figure 3B and C) were increased.
Source Asian Pac J Cancer Prev (2013). Figure 1. Dictamine
Method CCK-8 Assay
Cell Lines A549 cell line
Concentrations 100, 300 and 500 μM
Incubation Time 24 and 48 h
Results Moreover, the results that A549 cells treated with 300 μM Dic for different times (8, 12, 18 and 24 h) demonstrated that Dic induced A549 cells death in a time-dependent manner
Protocol (for reference only)
Cell Experiment
Cell lines A549 cell
Preparation method Cell cycle distribution was analyzed using FCM. Briefly, after cells were treated with 300 and 500 μM Dic for 24 h, the cells were harvested, washed twice with PBS, and fixed in 70 % ethanol at 4 °C for 1 h and centrifuged.
Concentrations 300 and 500 μM
Incubation time 24 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 199.21
Formula C12H9NO2
CAS Number 484-29-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] An FF, et al. Asian Pac J Cancer Prev. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells.

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Keywords: Dictamine, Dictamnine; Dectamine supplier, Apoptosis, inhibitors, activators

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