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DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
| Molecular Weight | 265.27 |
| Formula | C15H11N3O2 |
| CAS Number | 1263303-95-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 125 mg/mL (ultrasonic) |
| Storage | -20°C, protect from light |
| Related DHODH Products |
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| Leflunomide
Leflunomide (HWA486) is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM. |
| Teriflunomide
Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent. |
| Vidofludimus
Vidofludimus (4SC-101; SC12267) is an immunosuppressant that inhibits DHODH and inhibits il-17 secretion without affecting lymphocyte proliferation. |
| Brequinar
Brequinar is an effective Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 5.2 nM for human DHODH, and a broad-spectrum antiviral agent. |
| Orludodstat (BAY-2402234)
BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM. |
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