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DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9.
DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 µM.
| Molecular Weight | 332.16 |
| Formula | C11H7Cl2N3O3S |
| CAS Number | 672286-03-2 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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