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Desmethyl Erlotinib (CP-473420, OSI-774) is a free base of OSI-420, the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
| Molecular Weight | 379.41 |
| Formula | C21H21N3O4 |
| CAS Number | 183321-86-0 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| N-Desmethyl Imatinib
N-Desmethyl Imatinib |
| Desthiazolylmethyloxycarbonyl Ritonavir
Desthiazolylmethyloxycarbonyl Ritonavir is a metabolite of Ritonavir, which is a HIV protease inhibitor. |
| 4-Hydroxy phenyl carvedilol
4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker. |
| Omeprazole sulfone
Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor. |
| Duloxetine Phenolic Impurity
Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI). |
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