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δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research.
| Molecular Weight | 220.23 |
| Formula | C10H12N4O2 |
| CAS Number | 842964-18-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 75 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
[5] Kazumi Ishidoh, et al. Biol Chem. Processing and activation of lysosomal proteinases
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