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Dehydrolithocholic acid is a bile acid metabolite, which inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM).
| Molecular Weight | 374.56 |
| Formula | C24H38O3 |
| CAS Number | 1553-56-6 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | -20°C, sealed |
[2] Karl Bodin, et al. Biochim Biophys Acta. Novel pathways of bile acid metabolism involving CYP3A4
[4] T Tateyama, et al. Lipids. Metabolism of chenodeoxycholic acid in hamsters
| Related ROR Products |
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SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. |
| SR1078
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| SR 1001
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| GSK2981278
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| SR2211
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