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Dehydrocorydaline chloride

Cat. No. M13530

All AbMole products are for research use only, cannot be used for human consumption.

Dehydrocorydaline chloride Structure
Synonym:

13-Methylpalmatine chloride

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Quality Control & Documentation
Biological Activity

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline chloride elevates p38 MAPK activation. Dehydrocorydaline chloride has anti-inflammatory and anti-cancer activities. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

Chemical Information
Molecular Weight 401.88
CAS Number 10605-03-5
Solubility (25°C) DMSO 25 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Xiangru Zheng, et al. Aging (Albany NY). PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells

[2] Li Dai, et al. J Cell Physiol. STRIP2 silencing inhibits vascular smooth muscle cell proliferation and migration via P38-AKT-MMP-2 signaling pathway

[3] Motohiro Nonaka, et al. Malar J. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts

[4] Qiu-Yue Li, et al. Molecules. LC-MS/MS determination and pharmacokinetic study of dehydrocorydaline in rat plasma after oral administration of dehydrocorydaline and Corydalis yanhusuo extract

[5] Y Shoji, et al. Nihon Yakurigaku Zasshi. [Effects of dehydrocorydaline chloride on experimental gastric and duodenal ulcer]

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Keywords: Dehydrocorydaline chloride, 13-Methylpalmatine chloride supplier, Bcl-2, inhibitors, activators

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