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DDR1/2 inhibitor-2 is a DDR1/DDR2 inhibitor, with IC50 values less than 100 nM.
| Molecular Weight | 492.45 |
| Formula | C25H19F3N6O2 |
| CAS Number | 2908756-11-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Discoidin Domain Receptor Products |
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| DDR1-IN-4
DDR1-IN-4 is an effective and selective inhibitor of disk peptide domain receptor 1 (DDR1) autophosphorylation, with IC50 values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively. |
| WRG-28
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice. |
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