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DCC-3116 is a first-in-class, potent and selective orally inhibitor of ULK1/2 kinases and autophagy. ULK1/2 are kinases that receive and process input from nutrient and stress sensors to initiate autophagy. Inhibition of the MAPK pathway releases tonic inhibition of ULK1/2 and triggers autophagy as a survival mechanism, suggesting that ULK1/2 may provide a promising therapeutic target. DCC-3116 showed preclinical antitumor activity in combination with the MAPK kinase inhibitor trametinib.
| Molecular Weight | 535.6 |
| Formula | C26H36F3N7O2 |
| CAS Number | 2543673-19-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ULK Products |
|---|
| SBI-0206965
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 . |
| LYN-1604 2HCl
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. |
| ULK-101
ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM. |
| LYN-1604 dihydrochloride
LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC). |
| MRT68921 dihydrochloride
MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. |
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Products are for research use only. Not for human use. We do not sell to patients.
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