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DB818 

Cat. No. M30614

All AbMole products are for research use only, cannot be used for human consumption.

DB818  Structure

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Quality Control & Documentation
Biological Activity

DB818 is a potent inhibitor of Homeobox A9 (HOXA9). HOXA9 is a transcription factor regulating haematopoiesis and leukaemia cell proliferation, involving in acute myeloid leukaemia (AML). DB818 inhibits AML cell lines growth, induces apoptosis.

Chemical Information
Molecular Weight 360.44
Formula C19H16N6S
CAS Number 790241-43-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Yuri Sonoda, et al. Anticancer Res. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells

[2] Sabine Depauw, et al. J Med Chem. Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

[3] W David Wilson, et al. Curr Med Chem Anticancer Agents. Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity

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  Catalog
Abmole Inhibitor Catalog




Keywords: DB818  supplier, Apoptosis, inhibitors, activators

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